Upset Tummy - This is perhaps the number one complaint from those who experience complications from ingesting resveratrol. The reason for this is simple - it is called Emodin. The most common source of resveratrol is found in the Japanese Knotwood plant. It just so happens that this plant also contains high levels of emodin. Traditionally emodin has been used for constipation and pain related diseases, as well as proving very effective as a tumor inhibitor - but unless specifically needed, it is best to leave alone. Generally this is only a problem if the resveratrol is less than 50% purity, as the end product contains a higher level of the original Japanese Knotwood plant. Learn more about the effects of emodin & how it works...

Solution: As a rule, if the resveratrol used within the formulation is 98% & above in purity - virtually all of the available emodin has been removed during the extraction process.

 (extra alertness) - Some resveratrol users have experienced issues sleeping, as well as a "buzzing" type of feeling. Much of the time this subsides within the period of one week, and is thought to occur whilst the nervous system acclimates to the resveratrol compound.

Solution: If the resveratrol supplement is taken earlier in the day, and not after 3pm (just like coffee), then much of the insomnia - like symptoms will dissappear.

Minor Cold or Flu Like Symtoms - Again, resveratrol is a compound that stimulates the immune system, and this can sometimes trigger slight cold & flu-like symptoms until one's body acclimates. Initially resveratrol will suppress the activity of T & B cells and macrophages, as is evidenced by a significant inhibition in proliferation, antibody production and lymphokine secretion. Anto RJ, Mukhopadadhyay A, Denning K, Aggarwal BB. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome C release: its suppression by ectopic expression of Bcl-2 and Bcl-xL. Carcinogenesis. 2002;23:143–50

Solution: These symptoms tend to subside within the span of 5 - 7 days (if experienced at all), and tend to occur in those individuals ingesting large doses (above 1000mg daily). Keeping one's daily ingestion level below this amount is suggested.

Resveratrol - Compilation of Evidence Regarding Safety & Effigacy... This pdf contains a number of studies pertaining to the mechanics of the resveratrol compound & how it effects different biological pathways within the body.

Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics... This is a study supported by Cancer Research UK, and outlines the associated findings of the research.

LifeExtension - Living Longer, Healthier Lives with Resveratrol... David Nayor & Dale Kiefer have researched the Trans Resveratrol compound for the Life Extension publication (LE Magazine Febuary 2008).

Review of Toxicology Literature... This piece of research has been conducted by the National Institute of Environmental Health Sciences, and discusses the workings of resveratrol in relation to biology and so forth.